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eBook details

• Title: Marginalized Populations and Drug Addiction Research: Realism, Mistrust, And Misconception.
• Author : IRB: Ethics & Human Research
• Release Date : January 01, 2008
• Genre: Health & Fitness,Books,Health, Mind & Body,
• Pages : * pages
• Size : 232 KB

Description

Making a reasoned decision to participate in a randomized controlled trial requires, among other factors, understanding of the uncertain efficacy and risks of the experimental treatment, random assignment to interventions, and the use of placebos or other control interventions. Misunderstandings about randomized controlled trials have been characterized as examples of "therapeutic misconception." (1) According to Appelbaum, Lidz, and Grisso, the therapeutic misconception reflects the incorrect belief that individualized needs will be taken into account when a subject is randomized into a condition assignment, and the unreasonable expectation that research participation will result in individualized medical benefit. (2) One factor contributing to the therapeutic misconception is that prospective participants don't understand key features of the experimental process. (3) Horng and Grady have proposed that many instances identified as therapeutic misconception are better understood as cases either of therapeutic misestimation (i.e., underestimation of risk, overestimation of benefit, or both) or therapeutic optimism (i.e., hope for the best personal outcome). (4) In this regard, patients with more severe medical conditions may be more likely to overestimate therapeutic gains from participating in a randomized controlled trial. (5) As typologies for therapeutic misconception continue to evolve, empirical research has supported its expression across a range of disorders. (6) This has led to growing concern that the therapeutic misconception and related barriers to understanding may compromise the quality of informed consent. (7)

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